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Carriers of the A allele rs2294918 have reduced hepatic PNPLA3 messenger ribonucleic acid (mRNA) and protein levels, suggesting that this variant reduces PNPLA3 expression without affecting adiponutrin enzymatic activity [265]

Taken together, these heterogeneous findings highlight both biological plausibility and the methodological constraints that shape the current evidence base, motivating the integrative Discussion below

This contrasts to other beta-2 agonists that gain access to the same receptor via an aqueous pathway where diffusion is much more rapid (Anderson et al, 1994)

Environ Health Perspect (1994) 102 Suppl 10:1738